Application note: Raman-based high-throughput screening

1 October 2016  •  Author(s): Kaiser Optical Systems Polymorphic form ID Rapid screening of drug candidates Automated instrumentation for unattended data collection As the rate-determining step in early pharmaceutical development has moved from synthesis to analysis, new methods have been sought for rapidly screening drug candidates and for processing the data produced. The need to process an increased numbers of candidates has led to the development of the field of high-throughput screening (HTS). One of the most important properties of solid-state drug candidates is their polymorphic form. Many molecular solids, such as organic drug candidates, can crystallize in several different polymorphic forms, differing only in the space group of the extended solid or the conformation of the constituent molecules. Usually considered along with polymorphs are pseudopolymorphic versions of a compound such as solvates and hydrates. Differences in polymorphic form and in solvation or hydration may greatly affect the dissolution, stability, and bioavailability properties of the drug, so characterizing these forms early in a candidate’s lifetime and selectively producing only the desired polymorphic form or version is of the utmost importance in drug manufacture. The rest of this content is restricted to logged-in subscribers. Login or register (it's free!) to view the full content. ABB Analytical Measurement ACD/Labs ADInstruments Ltd Advanced Analytical Technologies GmbH Analytik Jena AG Astell Scientific Ltd Bibby Scientific Limited Bio-Rad Laboratories BioNavis Ltd Biopharma Group Black Swan Analysis Limited Charles Ischi AG | Kraemer Elektronik Cherwell Laboratories CI Precision Cobalt Light Systems Coulter Partners CPC Biotech srl Dassault Systèmes BIOVIA DiscoverX Edinburgh Instruments Enterprise System Partners (ESP) EUROGENTEC F.P.S. Food and Pharma Systems Srl IDBS JEOL Europe L.B. Bohle Maschinen + Verfahren GmbH Lab M Ltd. LabWare Linkam Scientific Instruments Limited Molins Technologies Multicore Dynamics Ltd Nanosurf New England Biolabs, Inc. Panasonic Biomedical Sales Europe B.V. PerkinElmer Inc ReAgent Russell Finex Limited Source BioScience Takara Clontech Tornado Spectral Systems Tuttnauer Watson-Marlow Fluid Technology Group Wickham Laboratories Limited Xylem Analytics YMC Europe GmbH Yusen LogisticsMore Companies